The FXa inhibitor class anticoagulants, consisting of Xarelto, Eliquis, Savaysa and a few others, was the dominant class ($2.9bn) in the $8bn anticoagulant market. In 34% of patients Dabigatran treatment was resumed pre-dischargedĬonclusion(s): In our study cohort lower dose Praxbind seemed to be effective in achieving adequate hemostasis in most of our bleeding and surgical patients.I made a call about Portola ( NASDAQ: PTLA) in July because I believed the company was in the right place at the right time. Eight patients died (mainly infection) and a single patient died from GI bleeding. In 28 patients response to Praxbind was graded adequate. Median pre Praxbind blood levels were 117ng/ml (IQR 323) while post administration median levels was 1 ng/ml (IQR 2). In 26% of patients (8/31) Praxbind was administered at LD. Dabigatran indication was atrial fibrillation in all patients. Results: Thirty one patients were included (14 females, median age 82 years). Response to treatment was graded as adequate, fair or non-responding In some patients dabigatran blood levels was taken immediately before and after (30 min.) administration. Praxbind dose (5 gm – HD, 2.5 gm – LD) and the decision for repeated administration was at the discretion of the treating physician. Methods: A retrospective cohort of consecutive patients treated with Praxbind between 01/ 2016 to 10/2021 for major bleeding or before urgent invasive procedures. The 5 g dose used was planned to reverse the 99 percentile of dabigatran levels, however lower doses can also neutralize dabigatran effectivelyĪims: To evaluate the use and effectiveness of Praxbind administered to bleeding and surgical patients at our center and study the effect of Praxbind dose Theme: Hemophilia and Rare Bleeding Disorders » Management of Bleeding and Traumaīackground: Praxbind is an antibody fragment that can effectively reverses the anticoagulant effect of Dabigatran in patients with bleeding and facing urgent surgery.
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